Depression & Partial Response

Here's some information on “major depressive disorder” (or “MDD”) and Partial Response you may find useful.

Here's some information on “major depressive disorder” (or “MDD”) and Partial Response you may find useful.

Major depressive disorder

Major depressive disorder is a serious medical illness affecting an estimated 21 million American adults. MDD can look different from person to person, and not everyone responds to medication the same way. For many, their antidepressant may not be working well enough. A large study showed that 2 out of 3 people taking an antidepressant still experienced symptoms of depression.

Learn more about symptoms of depression

Are you on an antidepressant but still struggling?

Take our questionnaire to take stock of your symptoms and discuss it with your healthcare provider.

Take the Questionnaire

Feeling stuck? It might be Partial Response.

If you're taking an antidepressant, but you’re still feeling depressed, you may be experiencing a Partial Response to your antidepressant. This is when your antidepressant may help to reduce your symptoms, but—due to a variety of reasons—only partially. Even though it could be hard to talk to your doctor, it's important to do so if you're still having symptoms. Many doctors are familiar with Partial Response.

Partial Response can have more than one underlying cause, and addressing it can be a multistep process that starts with a conversation.

If you’re still experiencing symptoms of depression, here are some potential topics you may
want to discuss with your doctor.

Time

Have I waited long enough for my treatment to start working?

Schedule

Am I taking my medication at the same time each day?

Drug/alcohol use

Does my medication interact with drugs or alcohol?

Lifestyle

Am I eating healthy and exercising?

Financial obstacles

Do I struggle paying for my prescription?

Transportation issues

Do I struggle to make appointments/pick up my prescription?

Mindfulness

Am I overstressed?

Talk therapy

Would seeing a therapist help?

Treatment plan

Could adding to or changing my treatment plan help?

Talk to your doctor about Partial Response.
Ask if adding REXULTI can help reduce your depression symptoms.

From the My Path Forward Video Series:

Depression is a journey (Episode 1)

Watch more from the My Path Forward Video Series

Watch more from the My Path Forward Video Series

Depression is a journey

Episode 1

Depression is a journey

Is there more I can do for my depression?

Episode 2

Is there more I can do for my depression?

Preparing for my doctor visit

Episode 3

Preparing for my doctor visit

How I had a productive doctor visit

Episode 4

How I had a productive doctor visit

Filling my prescription

Episode 5

Filling my prescription

Moving forward with my treatment plan

Episode 6

Moving forward with my treatment plan

Get a free journal

Get a complimentary journal

Tracking your progress is important. Sign Up to recieve a complimentary journal with helpful tips and tools to help in your journey.

Why REXULTI?

Want to see more videos in the series?

It’s important to know that antidepressants may increase suicidal thoughts or actions in some children, teenagers, or young adults within the first few months of treatment. Pay close attention to any changes, especially sudden changes in mood, behaviors, thoughts, or feelings and report such changes to the healthcare provider.

Symptoms of depression may last for 2 weeks or more, occurring nearly every day.

These may include:

A depressed mood most of the day (feeling sad, empty, hopeless, or on the verge of tears)
Loss of interest or pleasure in activities you once enjoyed
Weight loss (even when not on a diet) or experiencing weight gain
Decreases or increases in appetite
Difficulty sleeping or being overly tired
Restlessness or feeling slowed down
Fatigue or a loss of energy
Feeling worthless or guilty
A lack of concentration or difficulty with decision making
Thoughts of death or suicide

If you’ve been on an antidepressant for at least 2 months and are still dealing with symptoms of depression, talk to your healthcare provider to see if adding REXULTI may be an option for you.

Can REXULTI help?

Adding REXULTI was proven to reduce the symptoms of depression.

REXULTI® (brexpiprazole) savings card

Paying for REXULTI

If you are commercially insured, you may be eligible for the REXULTI Savings Card.^†

INDICATION and IMPORTANT SAFETY INFORMATION for REXULTI^® (brexpiprazole)

INDICATION:

REXULTI is a prescription medicine used:

with other antidepressant medicines to treat major depressive disorder (MDD) in adults.

It is not known if REXULTI is safe and effective in children with MDD.

IMPORTANT SAFETY INFORMATION:

Increased risk of death in elderly people with dementia-related psychosis. Medicines like REXULTI can raise the risk of death in elderly people who have lost touch with reality (psychosis) due to confusion and memory loss (dementia). REXULTI is not approved for the treatment of people with dementia-related psychosis.
Increased risk of suicidal thoughts and actions. Antidepressant medicines may increase suicidal thoughts and actions in some children, adolescents, and young adults especially within the first few months of treatment or when the dose is changed. Depression and other mental illnesses are the most important causes of suicidal thoughts and actions. Patients on antidepressants and their families or caregivers should watch for new or worsening depression symptoms, especially sudden changes in mood, behaviors, thoughts, or feelings. Report any change in these symptoms immediately to the doctor.

Do not take REXULTI if you are allergic to brexpiprazole or any of the ingredients in REXULTI.

REXULTI may cause serious side effects, including:

Stroke (cerebrovascular problems) in elderly people with dementia-related psychosis that can lead to death.
Neuroleptic malignant syndrome (NMS) is a serious condition that can lead to death. Call your healthcare provider or go to the nearest hospital emergency room right away if you have some or all of the following signs and symptoms of NMS: high fever; changes in your breathing, heart rate, and blood pressure; stiff muscles; confusion; increased sweating.
Uncontrolled body movements (tardive dyskinesia). REXULTI may cause movements that you cannot control in your face, tongue, or other body parts. Tardive dyskinesia may not go away, even if you stop taking REXULTI. Tardive dyskinesia may also start after you stop taking REXULTI.
Problems with your metabolism such as:
- high blood sugar (hyperglycemia) and diabetes. Increases in blood sugar can happen in some people who take REXULTI. Extremely high blood sugar can lead to coma or death. Your healthcare provider should check your blood sugar before you start, or soon after you start REXULTI and then regularly during long term treatment with REXULTI.
  Call your healthcare provider if you have any of these symptoms of high blood sugar during treatment with REXULTI:
  - feel very thirsty
  - feel very hungry
  - feel sick to your stomach
  - need to urinate more than usual
  - feel weak or tired
  - feel confused, or your breath smells fruity
- increased fat levels (cholesterol and triglycerides) in your blood.
  Your healthcare provider should check the fat levels in your blood before you start, or soon after you start REXULTI, and then periodically during treatment with REXULTI.
- weight gain. You and your healthcare provider should check your weight before you start and often during treatment with REXULTI.
Unusual and uncontrollable (compulsive) urges. Some people taking REXULTI have had strong unusual urges, to gamble and gambling that cannot be controlled (compulsive gambling). Other compulsive urges include sexual urges, shopping, and eating or binge eating. If you or your family members notice that you are having unusual strong urges, talk to your healthcare provider.
Low white blood cell count. Your healthcare provider may do blood tests during the first few months of treatment with REXULTI.
Decreased blood pressure (orthostatic hypotension). You may feel lightheaded or faint when you rise too quickly from a sitting or lying position.
Falls. REXULTI may make you sleepy or dizzy, may cause a decrease in your blood pressure when changing position (orthostatic hypotension), and can slow your thinking and motor skills which may lead to falls that can cause fractures or other injuries.
Seizures (convulsions).
Problems controlling your body temperature so that you feel too warm. Do not become too hot or dehydrated during treatment with REXULTI. Do not exercise too much. In hot weather, stay inside in a cool place if possible. Stay out of the sun. Do not wear too much clothing or heavy clothing. Drink plenty of water.
Difficulty swallowing that can cause food or liquid to get into your lungs.
Sleepiness, drowsiness, feeling tired, difficulty thinking and doing normal activities. Do NOT drive a car, operate machinery, or do other dangerous activities until you know how REXULTI affects you. REXULTI may make you feel drowsy.

Before taking REXULTI, tell your healthcare provider about all of your medical conditions, including if you:

have or have had heart problems or a stroke
have or have had low or high blood pressure
have or have had diabetes or high blood sugar or a family history of diabetes or high blood sugar. Your healthcare provider should check your blood sugar before you start REXULTI and during treatment with REXULTI.
have or have had high levels of total cholesterol, LDL cholesterol, or triglycerides, or low levels of HDL cholesterol
have or have had seizures (convulsions)
have or have had kidney or liver problems
have or have had a low white blood cell count
are pregnant or plan to become pregnant. REXULTI may harm your unborn baby. Taking REXULTI during your third trimester of pregnancy may cause your baby to have abnormal muscle movements or withdrawal symptoms after birth.
- Tell your healthcare provider if you become pregnant or think you are pregnant during treatment with REXULTI.
- If you become pregnant during treatment with REXULTI, talk to your healthcare provider about registering with the National Pregnancy Registry for Atypical Antipsychotics. You can register by calling 1-866-961-2388 or visit http://womensmentalhealth.org/clinical-and-research-programs/pregnancyregistry/.
are breastfeeding or plan to breastfeed. It is not known if REXULTI passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment with REXULTI.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. REXULTI and other medicines may affect each other causing possible serious side effects. REXULTI may affect the way other medicines work, and other medicines may affect how REXULTI works. Your healthcare provider can tell you if it is safe to take REXULTI with your other medicines. Do not start or stop any medicines during treatment with REXULTI without first talking to your healthcare provider.

The most common side effects of REXULTI include weight gain and restlessness or feeling like you need to move (akathisia).

These are not all the possible side effects of REXULTI. For more information, ask your healthcare provider or pharmacist.

You are encouraged to report side effects of REXULTI (brexpiprazole). Please contact Otsuka America Pharmaceutical, Inc. at 1-800-438-9927 or FDA at 1-800-FDA-1088 (www.fda.gov/medwatch).

Please read FULL PRESCRIBING INFORMATION, including BOXED WARNING, and MEDICATION GUIDE.

IMPORTANT SAFETY INFORMATION:

Increased risk of death in elderly people with dementia-related psychosis. Medicines like REXULTI can raise the risk of death in elderly people who have lost touch with reality (psychosis) due to confusion and memory loss (dementia). REXULTI is not approved for the treatment of people with dementia-related psychosis.
Increased risk of suicidal thoughts and actions. Antidepressant medicines may increase suicidal thoughts and actions in some children, adolescents, and young adults especially within the first few months of treatment or when the dose is changed. Depression and other mental illnesses are the most important causes of suicidal thoughts and actions. Patients on antidepressants and their families or caregivers should watch for new or worsening depression symptoms, especially sudden changes in mood, behaviors, thoughts, or feelings. Report any change in these symptoms immediately to the doctor.

Do not take REXULTI if you are allergic to brexpiprazole or any of the ingredients in REXULTI.

REXULTI may cause serious side effects, including:

Stroke (cerebrovascular problems) in elderly people with dementia-related psychosis that can lead to death.
Neuroleptic malignant syndrome (NMS) is a serious condition that can lead to death. Call your healthcare provider or go to the nearest hospital emergency room right away if you have some or all of the following signs and symptoms of NMS: high fever; changes in your breathing, heart rate, and blood pressure; stiff muscles; confusion; increased sweating.
Uncontrolled body movements (tardive dyskinesia). REXULTI may cause movements that you cannot control in your face, tongue, or other body parts. Tardive dyskinesia may not go away, even if you stop taking REXULTI. Tardive dyskinesia may also start after you stop taking REXULTI.
Problems with your metabolism such as:
- high blood sugar (hyperglycemia) and diabetes. Increases in blood sugar can happen in some people who take REXULTI. Extremely high blood sugar can lead to coma or death. Your healthcare provider should check your blood sugar before you start, or soon after you start REXULTI and then regularly during long term treatment with REXULTI.
  Call your healthcare provider if you have any of these symptoms of high blood sugar during treatment with REXULTI:
  - feel very thirsty
  - feel very hungry
  - feel sick to your stomach
  - need to urinate more than usual
  - feel weak or tired
  - feel confused, or your breath smells fruity
- increased fat levels (cholesterol and triglycerides) in your blood.
  Your healthcare provider should check the fat levels in your blood before you start, or soon after you start REXULTI, and then periodically during treatment with REXULTI.
- weight gain. You and your healthcare provider should check your weight before you start and often during treatment with REXULTI.
Unusual and uncontrollable (compulsive) urges. Some people taking REXULTI have had strong unusual urges, to gamble and gambling that cannot be controlled (compulsive gambling). Other compulsive urges include sexual urges, shopping, and eating or binge eating. If you or your family members notice that you are having unusual strong urges, talk to your healthcare provider.
Low white blood cell count. Your healthcare provider may do blood tests during the first few months of treatment with REXULTI.
Decreased blood pressure (orthostatic hypotension). You may feel lightheaded or faint when you rise too quickly from a sitting or lying position.
Falls. REXULTI may make you sleepy or dizzy, may cause a decrease in your blood pressure when changing position (orthostatic hypotension), and can slow your thinking and motor skills which may lead to falls that can cause fractures or other injuries.
Seizures (convulsions).
Problems controlling your body temperature so that you feel too warm. Do not become too hot or dehydrated during treatment with REXULTI. Do not exercise too much. In hot weather, stay inside in a cool place if possible. Stay out of the sun. Do not wear too much clothing or heavy clothing. Drink plenty of water.
Difficulty swallowing that can cause food or liquid to get into your lungs.
Sleepiness, drowsiness, feeling tired, difficulty thinking and doing normal activities. Do NOT drive a car, operate machinery, or do other dangerous activities until you know how REXULTI affects you. REXULTI may make you feel drowsy.

Before taking REXULTI, tell your healthcare provider about all of your medical conditions, including if you:

have or have had heart problems or a stroke
have or have had low or high blood pressure
have or have had diabetes or high blood sugar or a family history of diabetes or high blood sugar. Your healthcare provider should check your blood sugar before you start REXULTI and during treatment with REXULTI.
have or have had high levels of total cholesterol, LDL cholesterol, or triglycerides, or low levels of HDL cholesterol
have or have had seizures (convulsions)
have or have had kidney or liver problems
have or have had a low white blood cell count
are pregnant or plan to become pregnant. REXULTI may harm your unborn baby. Taking REXULTI during your third trimester of pregnancy may cause your baby to have abnormal muscle movements or withdrawal symptoms after birth.
- Tell your healthcare provider if you become pregnant or think you are pregnant during treatment with REXULTI.
- If you become pregnant during treatment with REXULTI, talk to your healthcare provider about registering with the National Pregnancy Registry for Atypical Antipsychotics. You can register by calling 1-866-961-2388 or visit http://womensmentalhealth.org/clinical-and-research-programs/pregnancyregistry/.
are breastfeeding or plan to breastfeed. It is not known if REXULTI passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment with REXULTI.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. REXULTI and other medicines may affect each other causing possible serious side effects. REXULTI may affect the way other medicines work, and other medicines may affect how REXULTI works. Your healthcare provider can tell you if it is safe to take REXULTI with your other medicines. Do not start or stop any medicines during treatment with REXULTI without first talking to your healthcare provider.

The most common side effects of REXULTI include weight gain and restlessness or feeling like you need to move (akathisia).

These are not all the possible side effects of REXULTI. For more information, ask your healthcare provider or pharmacist.

You are encouraged to report side effects of REXULTI (brexpiprazole). Please contact Otsuka America Pharmaceutical, Inc. at 1-800-438-9927 or FDA at 1-800-FDA-1088 (www.fda.gov/medwatch).

INDICATION:

REXULTI is a prescription medicine used:

with other antidepressant medicines to treat major depressive disorder (MDD) in adults.

It is not known if REXULTI is safe and effective in children with MDD.

Please read FULL PRESCRIBING INFORMATION, including BOXED WARNING, and MEDICATION GUIDE.

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