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Today, we
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What Is
Schizophrenia?

Schizophrenia

Everyone diagnosed with schizophrenia is affected differently. While the causes of the disorder are still being discovered, over the years, researchers have learned a lot about schizophrenia.

Today, we know that schizophrenia can affect how a person thinks, manages their emotions, makes decisions, and relates to other people. For many, managing the symptoms of schizophrenia requires a range of treatments along with the support of a caregiver and treatment team.

Actor portrayal

What are some of the symptoms of schizophrenia?

The symptoms of schizophrenia vary and may be disruptive or, in some cases, hard to notice. Just as there isn't a single lab or brain imaging test for schizophrenia, a single symptom can't be used to diagnose this condition. That's why healthcare providers must look at a number of signs and symptoms before making a diagnosis, including:

Positive symptoms

The positive symptoms of schizophrenia are associated with "losing touch" with reality. These symptoms may include:

  • Seeing, hearing, or even feeling things that no one else can
  • Beliefs in something even after it's proven to be false
  • Disorganized thinking, such as trouble organizing thoughts or connecting them logically
  • Involuntary movements or the lack of movement altogether

Negative symptoms

Negative symptoms may mean a disruption in normal everyday emotions and behaviors. These symptoms can sometimes be mistaken for depression or other conditions and may include:

  • Behavior where the person's face or voice does not move or show emotion
  • A lack of feeling pleasure in everyday life
  • An inability to take part in or to stick with planned activities
  • Talking only a little, even when asked to talk

Associated symptoms

These symptoms may be subtle compared to the positive symptoms mentioned above. They may include:

  • Difficulty with memory or paying attention
  • Difficulty understanding information to make decisions
  • Smiling or laughing for no appropriate reason
  • Depressed mood (loss of interest)
  • Lack of interest in food (refusing to eat)
  • Disturbed sleeping patterns

Working With your caregiver

If you have a caregiver in your life, he or she can be a valuable source of support for your treatment goals. Be sure to:

  • Let your caregiver, healthcare provider, and treatment team know about any symptoms you may be experiencing
  • Ask your caregiver to keep notes on your behavior and your treatment progress

Even if you don't have a caregiver, you can still find support through your healthcare provider, treatment team, or a local or nationally sponsored patient organization.

Getting treatment is important

If you've been diagnosed with schizophrenia, your healthcare provider may prescribe a medication like REXULTI® (brexpiprazole) because he or she thinks it may help reduce your symptoms. Keep in mind, treating schizophrenia often includes:

  • Medication
  • Talk therapy
  • Working with a treatment team

It's important to know that medicines like REXULTI can increase the risk of death in elderly people with dementia-related psychosis. Medicines like REXULTI can also raise the risk of death in elderly who have lost touch with reality (psychosis) due to confusion and memory loss (dementia). REXULTI is not approved for the treatment of patients with dementia-related psychosis.

What is a treatment team?

A treatment team is usually made up of a number of skilled mental health professionals dedicated to helping you reach your treatment goals. If you have a treatment team, it may include:

Psychiatrists
Psychiatrists are medical doctors who are able to diagnose mental health conditions and prescribe medications.

Psychologists
Psychologists are trained professionals who can provide therapy to help someone better manage their thoughts.

Nurse practitioners
Nurse practitioners can diagnose mental health conditions and, in some states, prescribe medication. They may be required to work under the guidance of a psychiatrist.

Physician assistants
Physician assistants are nationally certified and licensed to prescribe medications. Like nurse practitioners, they may also need to work under the guidance of a psychiatrist.

Registered nurses
Because of how closely they work with patients, nurses are often counted on to provide critical health information to the rest of the treatment team.

Social workers
The job of a social worker is to coordinate support and social services for patients.

Case managers
The case manager is a member of the treatment team in charge of making sure that patients receive the care and support they need.

Occupational therapists
An occupational therapist can help you set achievable goals based on your interests and abilities to help with your daily life.

Pharmacists
Before you take a new medication, it's a good idea to talk to your pharmacist to see if there could be any drug interactions.

Quick tip:

Fill your prescription as your healthcare provider tells you.

Start the conversation with
your doctor about REXULTI

Get the Doctor Discussion Guide

REXULTI may help
reduce your
symptoms
of schizophrenia

Learn Why

December 2017         11US16EBC0080 11US16EBC0080 11US16EBC0080

How were your symptoms of depression this week?

Think about how depression may still be affecting you.

Select the most appropriate response for each of the following statements. When finished, click 'Create My Discussion Guide' to receive a PDF of your responses along with the Doctor Discussion Guide to discuss with your healthcare provider. Please note that all answer fields must be completed. Your answers are completely confidential and will not be stored or shared.

( Select the closest answer )

During the past week, including today...

1.I felt sad or depressed.
2.I was not as interested in my usual activities.
3.My appetite was poor, and I didn’t feel like eating.
4.My appetite was much greater than usual.
5.I had difficulty sleeping.
6.I was sleeping too much.
7.I felt very fidgety, making it difficult to sit still.
8.I felt physically slowed down, like my body was stuck in mud.
9.My energy level was low.
10.I felt guilty.
11.I thought I was a failure.
12.I had problems concentrating.
13.I had more difficulties making decisions than usual.
14.I wished I was dead.
15.I thought about killing myself.
16.I thought that the future looked hopeless.
17.Overall, how much have symptoms of depression interfered with or caused difficulties in your life during the past week?
18.How would you rate your overall quality of life during the past week?

Download and print My Discussion Guide to help start the conversation with your doctor.

Please complete all questions.

Adapted from the Clinically Useful Depression Outcome Scale (CUDOS), developed by Mark Zimmerman, MD, Director of Outpatient Psychiatry at Rhode Island Hospital. Compr Psychiatry. Mar-Apr 2008;49(2):131-140.

This resource is provided for informational purposes only and is not intended as a substitute for a healthcare professional’s independent judgment. Always follow the healthcare advice of your doctor. Do not change the way you take your medication without talking with your doctor.

If you ever have suicidal thoughts, call your doctor or 911, or go to an emergency room. Take suicidal thoughts seriously and get help immediately.

Close

INDICATION and IMPORTANT SAFETY INFORMATION for REXULTI® (brexpiprazole)

INDICATION:
REXULTI is a prescription medicine used to treat:
  • Schizophrenia

It is not known if REXULTI is safe and effective in people under 18 years of age.

IMPORTANT SAFETY INFORMATION:

Increased risk of death in elderly people with dementia-related psychosis. Medicines like REXULTI can raise the risk of death in elderly who have lost touch with reality (psychosis) due to confusion and memory loss (dementia). REXULTI is not approved for the treatment of patients with dementia-related psychosis.

Do not take REXULTI if you are allergic to brexpiprazole or any of the ingredients in REXULTI. Allergic reactions have included rash, facial swelling, hives and itching, and anaphylaxis, which may include difficulty breathing, tightness in the chest, and swelling of the mouth, face, lips, or tongue.

REXULTI may cause serious side effects, including:
  • Stroke in elderly people (cerebrovascular problems) that can lead to death.
  • Neuroleptic Malignant Syndrome (NMS): Tell your healthcare provider right away if you have some or all of the following symptoms: high fever, stiff muscles, confusion, sweating, changes in pulse, heart rate, and blood pressure. These may be symptoms of a rare and serious condition that can lead to death. Call your healthcare provider right away if you have any of these symptoms.
  • Uncontrolled body movements (tardive dyskinesia). REXULTI may cause movements that you cannot control in your face, tongue or other body parts. Tardive dyskinesia may not go away, even if you stop taking REXULTI. Tardive dyskinesia may also start after you stop taking REXULTI.

  • Problems with your metabolism such as:
    • high blood sugar (hyperglycemia): Increases in blood sugar can happen in some people who take REXULTI. Extremely high blood sugar can lead to coma or death. If you have diabetes or risk factors for diabetes (such as being overweight or having a family history of diabetes), your healthcare provider should check your blood sugar before you start taking REXULTI and during your treatment.

      Call your healthcare provider if you have any of these symptoms of high blood sugar while taking REXULTI:
      • feel very thirsty
      • feel sick to your stomach
      • need to urinate more than usual
      • feel very hungry
      • feel weak or tired
      • feel confused, or your breath smells fruity
    • increased fat levels (cholesterol and triglycerides) in your blood.
    • weight gain. You and your healthcare provider should check your weight regularly.
  • Unusual urges. Some people taking REXULTI have had unusual urges, such as gambling, binge eating or eating that you cannot control (compulsive), compulsive shopping and sexual urges.

    If you or your family members notice that you are having unusual urges or behaviors, talk to your healthcare provider.

  • Low white blood cell count
  • Decreased blood pressure (orthostatic hypotension). You may feel lightheaded or faint when you rise too quickly from a sitting or lying position.
  • Seizures (convulsions)
  • Problems controlling your body temperature so that you feel too warm. Avoid getting over-heated or dehydrated while taking REXULTI.
    • Do not over-exercise.
    • Stay out of the sun. Do not wear too
      much or heavy clothing.
    • In hot weather, stay inside in a cool
      place if possible.
    • Drink plenty of water.
  • Difficulty swallowing that can cause food or liquid to get into your lungs.

Do not drive a car, operate machinery, or do other dangerous activities until you know how REXULTI affects you. REXULTI may make you feel drowsy.

Before taking REXULTI, tell your healthcare provider if you:
  • have diabetes or high blood sugar or a family history of diabetes or high blood sugar. Your healthcare provider should check your blood sugar before you start REXULTI and during your treatment.
  • have high levels of cholesterol, triglycerides, LDL-cholesterol, or low levels of HDL cholesterol
  • have or had seizures (convulsions)
  • have or had low or high blood pressure
  • have or had heart problems or a stroke
  • have or had a low white blood cell count
  • are pregnant or plan to become pregnant. It is not known if REXULTI may harm your unborn baby. Using REXULTI in the last trimester of pregnancy may cause muscle movement problems, medicine withdrawal symptoms, or both of these in your newborn.
  • are breastfeeding or plan to breastfeed. It is not known if REXULTI passes into your breast milk. You and your healthcare provider should decide if you will take REXULTI or breastfeed.

Tell your healthcare provider about all the medicines you take or recently have taken, including prescription medicines, over-the-counter medicines, vitamins and herbal supplements.

REXULTI and other medicines may affect each other causing possible serious side effects. REXULTI may affect the way other medicines work, and other medicines may affect how REXULTI works.

Your healthcare provider can tell you if it is safe to take REXULTI with your other medicines. Do not start or stop any medicines while taking REXULTI without talking to your healthcare provider first.

The most common side effect of REXULTI includes weight gain.

Tell your healthcare provider if you experience abnormal muscle spasms or contractions, which may be a sign of a condition called dystonia.

These are not all the possible side effects of REXULTI. For more information, ask your healthcare provider or pharmacist. Call your doctor for medical advice about your health or medicines, including side effects.

You are encouraged to report side effects of REXULTI (brexpiprazole). Please contact Otsuka America Pharmaceutical, Inc. at 1‑800‑438‑9927 or FDA at 1‑800‑FDA‑1088 (www.fda.gov/medwatch).

Please read U.S. FULL PRESCRIBING INFORMATION, including BOXED WARNING, and MEDICATION GUIDE, for REXULTI.

IMPORTANT SAFETY INFORMATION and INDICATION for
REXULTI® (brexpiprazole)
See More
Minimize
IMPORTANT SAFETY INFORMATION:

Increased risk of death in elderly people with dementia-related psychosis. Medicines like REXULTI can raise the risk of death in elderly who have lost touch with reality (psychosis) due to confusion and memory loss (dementia). REXULTI is not approved for the treatment of patients with dementia-related psychosis.

Do not take REXULTI if you are allergic to brexpiprazole or any of the ingredients in REXULTI. Allergic reactions have included rash, facial swelling, hives and itching, and anaphylaxis, which may include difficulty breathing, tightness in the chest, and swelling of the mouth, face, lips, or tongue.

REXULTI may cause serious side effects, including:
  • Stroke in elderly people (cerebrovascular problems) that can lead to death.
  • Neuroleptic Malignant Syndrome (NMS): Tell your healthcare provider right away if you have some or all of the following symptoms: high fever, stiff muscles, confusion, sweating, changes in pulse, heart rate, and blood pressure. These may be symptoms of a rare and serious condition that can lead to death. Call your healthcare provider right away if you have any of these symptoms.
  • Uncontrolled body movements (tardive dyskinesia). REXULTI may cause movements that you cannot control in your face, tongue or other body parts. Tardive dyskinesia may not go away, even if you stop taking REXULTI. Tardive dyskinesia may also start after you stop taking REXULTI.

  • Problems with your metabolism such as:
    • high blood sugar (hyperglycemia): Increases in blood sugar can happen in some people who take REXULTI. Extremely high blood sugar can lead to coma or death. If you have diabetes or risk factors for diabetes (such as being overweight or having a family history of diabetes), your healthcare provider should check your blood sugar before you start taking REXULTI and during your treatment.

      Call your healthcare provider if you have any of these symptoms of high blood sugar while taking REXULTI:
      • feel very thirsty
      • feel sick to your stomach
      • need to urinate more than usual
      • feel very hungry
      • feel weak or tired
      • feel confused, or your breath smells fruity
    • increased fat levels (cholesterol and triglycerides) in your blood.
    • weight gain. You and your healthcare provider should check your weight regularly.
  • Unusual urges. Some people taking REXULTI have had unusual urges, such as gambling, binge eating or eating that you cannot control (compulsive), compulsive shopping and sexual urges.

    If you or your family members notice that you are having unusual urges or behaviors, talk to your healthcare provider.

  • Low white blood cell count
  • Decreased blood pressure (orthostatic hypotension). You may feel lightheaded or faint when you rise too quickly from a sitting or lying position.
  • Seizures (convulsions)
  • Problems controlling your body temperature so that you feel too warm. Avoid getting over-heated or dehydrated while taking REXULTI.
    • Do not over-exercise.
    • Stay out of the sun. Do not wear too
      much or heavy clothing.
    • In hot weather, stay inside in a cool
      place if possible.
    • Drink plenty of water.
  • Difficulty swallowing that can cause food or liquid to get into your lungs.

Do not drive a car, operate machinery, or do other dangerous activities until you know how REXULTI affects you. REXULTI may make you feel drowsy.

Before taking REXULTI, tell your healthcare provider if you:
  • have diabetes or high blood sugar or a family history of diabetes or high blood sugar. Your healthcare provider should check your blood sugar before you start REXULTI and during your treatment.
  • have high levels of cholesterol, triglycerides, LDL-cholesterol, or low levels of HDL cholesterol
  • have or had seizures (convulsions)
  • have or had low or high blood pressure
  • have or had heart problems or a stroke
  • have or had a low white blood cell count
  • are pregnant or plan to become pregnant. It is not known if REXULTI may harm your unborn baby. Using REXULTI in the last trimester of pregnancy may cause muscle movement problems, medicine withdrawal symptoms, or both of these in your newborn.
  • are breastfeeding or plan to breastfeed. It is not known if REXULTI passes into your breast milk. You and your healthcare provider should decide if you will take REXULTI or breastfeed.

Tell your healthcare provider about all the medicines you take or recently have taken, including prescription medicines, over-the-counter medicines, vitamins and herbal supplements.

REXULTI and other medicines may affect each other causing possible serious side effects. REXULTI may affect the way other medicines work, and other medicines may affect how REXULTI works.

Your healthcare provider can tell you if it is safe to take REXULTI with your other medicines. Do not start or stop any medicines while taking REXULTI without talking to your healthcare provider first.

The most common side effect of REXULTI includes weight gain.

Tell your healthcare provider if you experience abnormal muscle spasms or contractions, which may be a sign of a condition called dystonia.

These are not all the possible side effects of REXULTI. For more information, ask your healthcare provider or pharmacist. Call your doctor for medical advice about your health or medicines, including side effects.

You are encouraged to report side effects of REXULTI (brexpiprazole). Please contact Otsuka America Pharmaceutical, Inc. at 1‑800‑438‑9927 or FDA at 1‑800‑FDA‑1088 (www.fda.gov/medwatch).

INDICATION:
REXULTI is a prescription medicine used to treat:
  • Schizophrenia

It is not known if REXULTI is safe and effective in people under 18 years of age.

Please read U.S. FULL PRESCRIBING INFORMATION, including BOXED WARNING, and MEDICATION GUIDE, for REXULTI.

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