Helpful Tools

Whether you're already taking REXULTI or considering treatment, get the tools and resources you may need.

How have you been feeling these last 2 weeks?

Answer a few questions about your depression symptoms.

Complete this questionnaire your doctor knows as the PHQ-9 depression tool. It can help you understand how depression may be affecting you. Share the PDF of your responses along with a list of questions with your doctor to help you make the most of your next visit.

Get Started

Talking to your doctor?

REXULTI Doctor Discussion Guide

Considering talking to your healthcare provider about adding REXULTI, but not sure where to begin? This helpful discussion guide provides questions to ask your healthcare provider.

Get The Doctor Discussion Guide

Get to know REXULTI

REXULTI works with your antidepressant to help build on the progress you've already made. Learn how adding REXULTI can help manage your depression with this informative guide.

Paying for REXULTI

If you are commercially insured, you may be eligible for the REXULTI Savings Card.*

*This program is not health insurance. Further conditions apply.

My Wellness Guide

We hope these simple tips may help in your daily life. Share them with your doctor. Together you can decide which ones could make sense for you.

Mindfulness Coloring Book

You don’t need to be the next Picasso to benefit from a bit of artistic expression. We created this fun and engaging book, especially for you. Give it a try!

Daily Dose of Inspiration

If you could use a dose of inspiration in the months ahead, try adding these words to your life.

Progress Tracker

Track your progress and review your accomplishments at your next doctor's appointment.

Resources and Organizations

Bring Change 2 Mind

This national anti-stigma campaign is dedicated to removing misconceptions about mental illness.

bringchange2mind.org

Mental Health America

The leading community-based non-profit network in the United States, supplying resources for living a mentally healthy life.

mhanational.org

National Alliance on Mental Illness (NAMI)

This is the nation’s largest grassroots mental health organization.

nami.org
or call 1-800-950-6264

National Council for Behavioral Health (National Council)

A government organization working to transform the understanding and treatment of mental illnesses.

thenationalcouncil.org
or call 1-202-684-7457

National Institute of Mental Health (NIMH)

A government organization working to transform the understanding and treatment of mental illnesses.

nimh.nih.gov
or call 1-866-615-6464

Substance Abuse and Mental Health Services Administration (SAMHSA)

Resource for substance abuse and mental health.

samhsa.gov

or call 1-877-SAMHSA-7 (877-726-4727) | 1-800-487-4889 (TDD)

The organizations and resources listed are not affiliated with nor are they controlled or influenced by Otsuka America Pharmaceutical, Inc. (OAPI) and Lundbeck. OAPI or Lundbeck may have entered into limited fee-for-service arrangements with some of the listed organizations and resources from time to time. OAPI and Lundbeck are providing information to you about these organizations and resources merely as a convenience, and OAPI and Lundbeck shall not be liable for any use of this information, or for any information obtained from or provided by these organizations or resources. OAPI and Lundbeck are not responsible for the consequences of your use of any information provided by these organizations and resources.

Can REXULTI Help?

Adding REXULTI was proven to reduce the symptoms of depression.

Paying for REXULTI

If you are commercially insured, you may be eligible for the REXULTI Savings Card.*

IMPORTANT SAFETY INFORMATION:

Increased risk of death in elderly people with dementia-related psychosis. Medicines like REXULTI can raise the risk of death in elderly people who have lost touch with reality (psychosis) due to confusion and memory loss (dementia). REXULTI is not approved for the treatment of people with dementia-related psychosis.
Increased risk of suicidal thoughts and actions. Antidepressant medicines may increase suicidal thoughts and actions in some children, adolescents, and young adults especially within the first few months of treatment or when the dose is changed. Depression and other mental illnesses are the most important causes of suicidal thoughts and actions. Patients on antidepressants and their families or caregivers should watch for new or worsening depression symptoms, especially sudden changes in mood, behaviors, thoughts, or feelings. Report any change in these symptoms immediately to the doctor.

Do not take REXULTI if you are allergic to brexpiprazole or any of the ingredients in REXULTI.

REXULTI may cause serious side effects, including:

Stroke (cerebrovascular problems) in elderly people with dementia-related psychosis that can lead to death.
Neuroleptic malignant syndrome (NMS) is a serious condition that can lead to death. Call your healthcare provider or go to the nearest hospital emergency room right away if you have some or all of the following signs and symptoms of NMS: high fever; changes in your breathing, heart rate, and blood pressure; stiff muscles; confusion; increased sweating.
Uncontrolled body movements (tardive dyskinesia). REXULTI may cause movements that you cannot control in your face, tongue, or other body parts. Tardive dyskinesia may not go away, even if you stop taking REXULTI. Tardive dyskinesia may also start after you stop taking REXULTI.
Problems with your metabolism such as:
- high blood sugar (hyperglycemia) and diabetes. Increases in blood sugar can happen in some people who take REXULTI. Extremely high blood sugar can lead to coma or death. Your healthcare provider should check your blood sugar before you start, or soon after you start REXULTI and then regularly during long term treatment with REXULTI.
  Call your healthcare provider if you have any of these symptoms of high blood sugar during treatment with REXULTI:
  - feel very thirsty
  - feel very hungry
  - feel sick to your stomach
  - need to urinate more than usual
  - feel weak or tired
  - feel confused, or your breath smells fruity
- increased fat levels (cholesterol and triglycerides) in your blood.
  Your healthcare provider should check the fat levels in your blood before you start, or soon after you start REXULTI, and then periodically during treatment with REXULTI.
- weight gain. You and your healthcare provider should check your weight before you start and often during treatment with REXULTI.
Unusual and uncontrollable (compulsive) urges. Some people taking REXULTI have had strong unusual urges, to gamble and gambling that cannot be controlled (compulsive gambling). Other compulsive urges include sexual urges, shopping, and eating or binge eating. If you or your family members notice that you are having unusual strong urges, talk to your healthcare provider.
Low white blood cell count. Your healthcare provider may do blood tests during the first few months of treatment with REXULTI.
Decreased blood pressure (orthostatic hypotension). You may feel lightheaded or faint when you rise too quickly from a sitting or lying position.
Falls. REXULTI may make you sleepy or dizzy, may cause a decrease in your blood pressure when changing position (orthostatic hypotension), and can slow your thinking and motor skills which may lead to falls that can cause fractures or other injuries.
Seizures (convulsions).
Problems controlling your body temperature so that you feel too warm. Do not become too hot or dehydrated during treatment with REXULTI. Do not exercise too much. In hot weather, stay inside in a cool place if possible. Stay out of the sun. Do not wear too much clothing or heavy clothing. Drink plenty of water.
Difficulty swallowing that can cause food or liquid to get into your lungs.
Sleepiness, drowsiness, feeling tired, difficulty thinking and doing normal activities. Do NOT drive a car, operate machinery, or do other dangerous activities until you know how REXULTI affects you. REXULTI may make you feel drowsy.

Before taking REXULTI, tell your healthcare provider about all of your medical conditions, including if you:

have or have had heart problems or a stroke
have or have had low or high blood pressure
have or have had diabetes or high blood sugar or a family history of diabetes or high blood sugar. Your healthcare provider should check your blood sugar before you start REXULTI and during treatment with REXULTI.
have or have had high levels of total cholesterol, LDL cholesterol, or triglycerides, or low levels of HDL cholesterol
have or have had seizures (convulsions)
have or have had kidney or liver problems
have or have had a low white blood cell count
are pregnant or plan to become pregnant. REXULTI may harm your unborn baby. Taking REXULTI during your third trimester of pregnancy may cause your baby to have abnormal muscle movements or withdrawal symptoms after birth.
- Tell your healthcare provider if you become pregnant or think you are pregnant during treatment with REXULTI.
- If you become pregnant during treatment with REXULTI, talk to your healthcare provider about registering with the National Pregnancy Registry for Atypical Antipsychotics. You can register by calling 1-866-961-2388 or visit http://womensmentalhealth.org/clinical-and-research-programs/pregnancyregistry/.
are breastfeeding or plan to breastfeed. It is not known if REXULTI passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment with REXULTI.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. REXULTI and other medicines may affect each other causing possible serious side effects. REXULTI may affect the way other medicines work, and other medicines may affect how REXULTI works. Your healthcare provider can tell you if it is safe to take REXULTI with your other medicines. Do not start or stop any medicines during treatment with REXULTI without first talking to your healthcare provider.

The most common side effects of REXULTI include weight gain and restlessness or feeling like you need to move (akathisia).

These are not all the possible side effects of REXULTI. For more information, ask your healthcare provider or pharmacist.

You are encouraged to report side effects of REXULTI (brexpiprazole). Please contact Otsuka America Pharmaceutical, Inc. at 1-800-438-9927 or FDA at 1-800-FDA-1088 (www.fda.gov/medwatch).

INDICATION:

REXULTI is a prescription medicine used:

with other antidepressant medicines to treat major depressive disorder (MDD) in adults.

It is not known if REXULTI is safe and effective in children with MDD.

Please read FULL PRESCRIBING INFORMATION, including BOXED WARNING, and MEDICATION GUIDE.